Comparison of low- and high-concentration (270 and 320 mg I/ml) iso-osmolar iodinated contrast media in coronary CT angiography: a randomized prospective single-center blinded study

• Published in: Vestnik rentgenologii i radiologii no. 4; pp. 5 - 12
• Main Authors: Sinitsyn, V E, Komarova, M A, Mershina, E A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.2014
• Subjects: Aged; Contrast Media - administration & dosage; Contrast Media - adverse effects; Coronary Angiography - methods; Coronary Disease - diagnosis; Coronary Vessels - pathology; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Humans; Male; Middle Aged; Multidetector Computed Tomography - methods; Radiographic Image Enhancement; Treatment Outcome; Triiodobenzoic Acids - administration & dosage; Triiodobenzoic Acids - adverse effects
• ISSN: 0042-4676

To compare the image quality at coronary multidetector computed tomography (MDCT) using low-dose and low-iodine protocol study in comparison with the standard protocol. In study included 60 patients undergoing coronary computed tomography angiography. All examinations were performed with 64-row MDCT using prospective ECG-gating and ASIR 40%. 30 patients were examined using a low-concentration (Iodixanol, 270 mg I/ml) iodinated contrast medium and low tube voltage (80 kV) (group 1), 30 patients--using of high-concentration (Iodixanol, 320 mg I/ml) iodinated contrast medium and standard tube voltage (120 kV) (group 2). Image quality of coronary arteries was evaluated using a four-point grading scale, images were randomised. Intra-arterial density was measured for the proximal and distal segments of left anterior descending artery (LAD) and right coronary artery (RCA). Age, heart rate, BMI and scan parameters were not statistically different between the two groups. Analysis of coronaries visualization revealed the same image quality for group 1 and group 2 (image quality scores were 1.28 ± 0.28 vs. 1.34 ± 0.29, p = 0.4). There was no significant difference between mean enhancement values in the distal segments of RCA and LAD for the two groups. Intraarterial density for proximal LAD and proximal RCA for the nazpyara, umepamuenas group 2 were significantly lower (p < 0.05) than those values for the group 1. Conclusion. Theuse of low-dose and low-iodine protocol can be beneficial for patient safety and or image quality ithout loss of diag- stic information.