Effect of Lentiviral Vector-Mediated CXCR4 Gene Overexpression on Mesenchymal Stem Cell Homing Capacity

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 26; no. 5; p. 1543
• Main Authors: Chen, Wei, Zhou, Dian, Li, Ya-Ru, Liu, Jun-Xiu, Wang, Xiang-Min, Zhu, Feng, Xu, Kai-Lin
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2018
• Subjects: Animals; Bone Marrow; Bone Marrow Cells; Chemokine CXCL12; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Receptors, CXCR4; Whole-Body Irradiation

To explore the effects of lentiviral-mediated CXC chemokine receptor-4（CXCR-4）gene over-expression on the homing capacity of mesenchymal stem cells（MSC）in vivo. The MSC overexpressing CXCR-4 were constructed by using the lentiviral vector-mediated mouse MSC overexpressing the CXCR-4 gene. The BALB/c...