Maternal-fetal outcomes of lamivudine treatment administered during late pregnancy to highly viremic mothers with HBeAg+ chronic hepatitis B
To evaluate the therapeutic efficacy and safety of lamivudine treatment in late pregnancy by analyzing the maternal-fetal outcomes of chronic hepatitis B (CHB) mothers featuring hepatitis B e antigen (HBeAg)-positivity and highly viremic status. A total of 256 pregnant women in the second or third t...
Saved in:
Published in | Zhonghua gan zang bing za zhi Vol. 20; no. 12; p. 888 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
01.12.2012
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | To evaluate the therapeutic efficacy and safety of lamivudine treatment in late pregnancy by analyzing the maternal-fetal outcomes of chronic hepatitis B (CHB) mothers featuring hepatitis B e antigen (HBeAg)-positivity and highly viremic status.
A total of 256 pregnant women in the second or third trimester with monoinfected CHB, HBeAg-positivity, and HBV DNA more than 6 log10 copies/mL were divided into two groups: lamivudine (lam) treatment (n=164) or no treatment (controls; n=92). All infants were treated with hepatitis B immune globin (HBIg; 200 IU) within 12 hrs of birth and 15 days later, and were given the recombinant HBV vaccine (20 mug) at 0, 1 and 6 months. All infants were followed-up to at least seven months and hepatitis B surface antigen (HBsAg) and HBV DNA levels were used to determine perinatal transmission (PT) rates. The mothers' data from routine blood analysis, tests of hepatic and renal function, detection of HBV markers and HBV DNA were retrospectively analyzed to determine changes assoc |
---|---|
AbstractList | To evaluate the therapeutic efficacy and safety of lamivudine treatment in late pregnancy by analyzing the maternal-fetal outcomes of chronic hepatitis B (CHB) mothers featuring hepatitis B e antigen (HBeAg)-positivity and highly viremic status.
A total of 256 pregnant women in the second or third trimester with monoinfected CHB, HBeAg-positivity, and HBV DNA more than 6 log10 copies/mL were divided into two groups: lamivudine (lam) treatment (n=164) or no treatment (controls; n=92). All infants were treated with hepatitis B immune globin (HBIg; 200 IU) within 12 hrs of birth and 15 days later, and were given the recombinant HBV vaccine (20 mug) at 0, 1 and 6 months. All infants were followed-up to at least seven months and hepatitis B surface antigen (HBsAg) and HBV DNA levels were used to determine perinatal transmission (PT) rates. The mothers' data from routine blood analysis, tests of hepatic and renal function, detection of HBV markers and HBV DNA were retrospectively analyzed to determine changes assoc |
Author | Jiang, Hong-xiu Wang, Cui-min Han, Guo-rong Ji, Ying |
Author_xml | – sequence: 1 givenname: Hong-xiu surname: Jiang fullname: Jiang, Hong-xiu organization: Department of Obstetrics and Gynecology, the Second Affiliated Hosptial of Southeast University, Nanjing, China – sequence: 2 givenname: Guo-rong surname: Han fullname: Han, Guo-rong – sequence: 3 givenname: Cui-min surname: Wang fullname: Wang, Cui-min – sequence: 4 givenname: Ying surname: Ji fullname: Ji, Ying |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23522247$$D View this record in MEDLINE/PubMed |
BookMark | eNo9UMtKAzEUzaJia-0vSJaCzJjHvLpsi1qh4kbX5U7mphOZZIYkrfQf_GgHfMCBA-e1OFdk4nqHhNxylsqyYPfKQvqRmhBcyhkrE5nxKhWMi3QEY3JCZv_6lCxCMPWo8rwQeXZJpkLmQoisnJGvF4joHXSJxggd7Y9R9RYD7TXtwJrTsTEOafQI0aKLFBprnAljCRvaHL1xhzEYkQ4eDw6cOtPY09Yc2u5MT8ajNYraPrboA_00saXbNa4Od1S1vnej1-IA0UQT6PqaXGjoAi5-eU7eHx_eNttk9_r0vFntkoGLIiaKKVnjkmvQeaHZUtfAABTPGV9yJWrBeVWLDFklaymhKiuOSuuikjLPVFmJObn52R2OtcVmP3hjwZ_3f7eIb-1sbS0 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.3760/cma.j.issn.1007-3418.2012.12.003 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
ExternalDocumentID | 23522247 |
Genre | Controlled Clinical Trial English Abstract Journal Article |
GroupedDBID | --- -05 2B. 2C~ 92F 92I ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CGR CIEJG CUY CVF CW9 ECM EIF F5P NPM TCJ TGQ U1G U5O |
ID | FETCH-LOGICAL-p126t-c0c3be91faf56f09fba0aac150191c2b2118b24e083b33a8781ecff683354c782 |
ISSN | 1007-3418 |
IngestDate | Thu May 23 23:18:34 EDT 2024 |
IsPeerReviewed | false |
IsScholarly | true |
Issue | 12 |
Language | Chinese |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p126t-c0c3be91faf56f09fba0aac150191c2b2118b24e083b33a8781ecff683354c782 |
PMID | 23522247 |
ParticipantIDs | pubmed_primary_23522247 |
PublicationCentury | 2000 |
PublicationDate | 2012-Dec |
PublicationDateYYYYMMDD | 2012-12-01 |
PublicationDate_xml | – month: 12 year: 2012 text: 2012-Dec |
PublicationDecade | 2010 |
PublicationPlace | China |
PublicationPlace_xml | – name: China |
PublicationTitle | Zhonghua gan zang bing za zhi |
PublicationTitleAlternate | Zhonghua Gan Zang Bing Za Zhi |
PublicationYear | 2012 |
SSID | ssib003156254 ssib001103527 ssib051368310 ssj0042015 ssib017477315 |
Score | 2.0279443 |
Snippet | To evaluate the therapeutic efficacy and safety of lamivudine treatment in late pregnancy by analyzing the maternal-fetal outcomes of chronic hepatitis B (CHB)... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 888 |
SubjectTerms | Adult Antiviral Agents - therapeutic use DNA, Viral - blood Female Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - transmission Humans Infant Infectious Disease Transmission, Vertical - prevention & control Lamivudine - therapeutic use Mothers Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - virology Pregnancy Outcome Pregnancy Trimester, Third Treatment Outcome Young Adult |
Title | Maternal-fetal outcomes of lamivudine treatment administered during late pregnancy to highly viremic mothers with HBeAg+ chronic hepatitis B |
URI | https://www.ncbi.nlm.nih.gov/pubmed/23522247 |
Volume | 20 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELa6ICEuCMRreckHDkhRSuykeRy3K6BC2j3tSisuKzu126BtU4lkBfkN_Cn-GTO2k5iK9yWq4tROMp_G3zgznwl5qZapKApRgAWYDpNMLEOpIGplikfxEubfVOHSwMlpujhP3l_MLiaTb17WUtvIadn9tK7kf6wK58CuWCX7D5YdOoUT8BvsC0ewMBz_ysYnwko4h1phTWPdNjCKVZEFQ1fX7RI5pJdL7pRycX_OvkDxCvpApYAVKm8YKooKxldfgmtwhpg4vzE1Wq4KbjFXR-Ac5kFpRXWBaGJKdlN9cts3O577YV1vV-tWBCvwH52AcSQO1omgW1dD1k7lFqsXcHH4uWpHd2h84bu2DmGU1bjoby8_bqtwU23Hbsw80s_BbgmDcS8dxHpdXC-F6TT33TKPfPhxz8nmdiPAfeeP6T1gsXIjph9Nv9OhX0zh42bZ1wgqNB42dhsDDo5ElFvxz9-37slz900H5CDL0cWeestFwK2g2YvXGMabgwOEaDDL4pGPzVic5oZvWyqRwG3PzOd69xy3yCv3oK__9Jiocu1ubS9iMszp7C6540IeemTxe49MuvV98vVH7NIeu7TWdMQuHbBLfexSi12K2KUDdmlTU4td6rBLHXYpYpca7AbUIZcOyKXzB-T87Zuz40XodgYJd4ynTVhGZSxVwbTQs1RHhZYiEqKE4IYVrOSSQ9gseaIgvpBxLPIsZ6rUOsUKw6QEUvyQ3NjWW_WYUKUz-AfTPAeiG3EhcX8EERcadaeSKD8kj-zLu9xZ-ZfL_rU--WXLU3J7hPkzclODv1HPgbw28oUByHe-jpKv |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Maternal-fetal+outcomes+of+lamivudine+treatment+administered+during+late+pregnancy+to+highly+viremic+mothers+with+HBeAg%2B+chronic+hepatitis+B&rft.jtitle=Zhonghua+gan+zang+bing+za+zhi&rft.au=Jiang%2C+Hong-xiu&rft.au=Han%2C+Guo-rong&rft.au=Wang%2C+Cui-min&rft.au=Ji%2C+Ying&rft.date=2012-12-01&rft.issn=1007-3418&rft.volume=20&rft.issue=12&rft.spage=888&rft_id=info:doi/10.3760%2Fcma.j.issn.1007-3418.2012.12.003&rft_id=info%3Apmid%2F23522247&rft_id=info%3Apmid%2F23522247&rft.externalDocID=23522247 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1007-3418&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1007-3418&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1007-3418&client=summon |