Clinicopathological characteristics of the CD8 + T lymphocytes infiltration and its mechanism in distinct molecular subtype of medulloblastoma

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 56; no. 3; p. 512
• Main Authors: Chai, Xiaodong, Sun, Ziwen, Li, Haishuang, Zhu, Liangyi, Liu, Xiaodan, Liu, Yantao, Pei, Fei, Chang, Qing
• Format: Journal Article
• Language: Chinese
• Published: China 18.06.2024
• Subjects: CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cerebellar Neoplasms - classification; Cerebellar Neoplasms - genetics; Cerebellar Neoplasms - immunology; Cerebellar Neoplasms - metabolism; Cerebellar Neoplasms - pathology; Chemokine CXCL11 - genetics; Chemokine CXCL11 - metabolism; Female; Humans; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Male; Medulloblastoma - classification; Medulloblastoma - genetics; Medulloblastoma - immunology; Medulloblastoma - metabolism; Medulloblastoma - pathology; Prognosis; Receptors, CXCR3 - genetics; Receptors, CXCR3 - metabolism; CD8-positive T-lymphocytes; Tumor microenvironment; Medulloblastoma; Chemokine CXCL11

To investigate the characteristics of the CD8 T cells infiltration from the 4 subtypes in medulloblastoma (MB), to analyze the relationship between CD8 T cells infiltration and prognosis, to study the function of C-X-C motif chemokine ligand 11 (CXCL11) and its receptor in CD8 T cells infiltration i...