(18)F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier - Liow, Jeih-San; Zoghbi, Sami S; Hu, Shuo; Hall, Matthew D; Hines, Christina S; Shetty, H Umesha; Araneta, Maria D; Page, Emily M; Pike, Victor W; Kreisl, William C; Herscovitch, Peter; Gottesman, Michael M; et al. (NeuroImage (Orlando, Fla.), 2016)
Keywords: Adult; ATP Binding Cassette Transporter, Subfamily B - metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; Blood-Brain Barrier - metabolism; Capillary Permeability - physiology; Cyclohexanes - pharmacokinetics; Female; Humans; Male; Multidrug Resistance-Associated Proteins - metabolism; Neoplasm Proteins - metabolism; Piperazines - pharmacokinetics; Positron-Emission Tomography - methods; Radiopharmaceuticals - pharmacokinetics; Receptor, Serotonin, 5-HT1A - metabolism; Reproducibility of Results; Sensitivity and Specificity; 5-HT(1A); P-gp; Blood brain barrier; Efflux transporter; PET