A Case of Liver Metastasis of Colorectal Cancer Successfully Treated with Hepatic Arterial Infusion Chemotherapy after Systemic Chemotherapy Was Difficult to Administer

• Published in: Gan to kagaku ryoho Vol. 50; no. 1; p. 110
• Main Authors: Kaneko, Jun, Isogai, Jun, Hayashi, Kumiko, Takatsuno, Yasushi, Okamoto, Shota, Hayakawa, Tomohiro, Hasegawa, Kumi, Maejima, Kentaro
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.01.2023
• Subjects: Antineoplastic Combined Chemotherapy Protocols - adverse effects; Colorectal Neoplasms - surgery; Fluorouracil; Hepatic Artery - pathology; Humans; Infusions, Intra-Arterial; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Liver Neoplasms - surgery; Male; Sigmoid Neoplasms - drug therapy; Sigmoid Neoplasms - pathology; Sigmoid Neoplasms - surgery
• ISSN: 0385-0684

The patient underwent partial sigmoid colon resection for sigmoid colon cancer with hyper CEA blood(1,110.6 ng/mL) and concurrent liver metastases mostly in the right lobe of the liver, followed by systemic chemotherapy(SOX plus BEV). Seven courses of chemotherapy resulted in PR on imaging, and CEA was reduced to 5.0 ng/mL, which was within reference values. As he continued chemotherapy, frequent hematologic toxicities and adverse events forced frequent dose reductions and changes in the chemotherapy schedule. About 2 years after surgery(19 courses of SOX plus BEV), the liver metastases became slightly enlarged on imaging, and the CEA was also increasing. The patient did not wish to undergo systemic chemotherapy and requested hepatic arterial infusion chemotherapy(HAIC), which has relatively few side effects and adverse events. HAIC with pyrimidine fluoride alone is ongoing for 22 courses, and tumor markers have decreased again with PR on imaging. Performance status has been good without hematologic toxicity or adverse events for approximately 1 year during the course of HAIC. HAIC is a weakly recommended therapy in the colorectal cancer treatment guidelines, but it is considered one of the most effective therapies with relatively few side effects.