Correlation of Tp-e interval and Tp-e/Q-T ratio with malignant ventricular arrhythmia in patients with implantable cardioverter-defibrillator for primary prevention

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 36; no. 3; p. 401
• Main Authors: Zhu, Ting-Yan, Teng, Shu-En, Chen, Yan-Yu, Liu, Shen-Rong, Meng, Su-Rong, Peng, Jian
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2016
• Subjects: Death, Sudden, Cardiac - prevention & control; Defibrillators, Implantable; Electrocardiography; Heart Failure - therapy; Humans; Primary Prevention; ROC Curve; Tachycardia, Ventricular - prevention & control; Ventricular Fibrillation; Ventricular Function, Left
• ISSN: 1673-4254

To investigate whether Tpeak-Tend interval (Tp-e) and Tp-e/QT ratio are associated with malignant ventricular arrhythmia in patients with implantable cardioverter-defibrillator (ICD) for primary prevention. A cohort of 68 consecutive patients with chronic heart failure undergoing standard ICD for primary prevention indications (NYHA function class II-III, left ventricular ejection fraction ≤35%, systolic cardiomyopathy without prior malignant ventricular arrhythmia) were enrolled in this study. The patients were followed up for 18-48 months and were divided into high-risk group and low-risk group according to the occurrence of the endpoint events of sudden cardiac death (SCD), ventricular tachycardia (VT), or ventricular fibrillation (VF). Electrocardiographic and echocardiographic characteristics, Tp-e, and Tp-e/QT ratio were analyzed in all cases before ICD implantation. During the follow-up, ICD shock for sustained ventricular tachycardia or ventricular fibrillation occurred in 11 patients; nonsustained ve