The therapeutic mechanisms of sirolimus treatment for ischemic-type biliary lesions after liver transplantation

• Published in: Chung-hua wai kʿo tsa chih Vol. 51; no. 8; p. 691
• Main Authors: Li, Chuan-yun, Lu, Shi-chun, Lai, Wei, Liu, Yuan, Zeng, Tao-bing, Guo, Qing-liang, Lin, Dong-dong, Wu, Ju-shan, Wang, Meng-long, Li, Ning
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2013
• Subjects: Adult; Bile Duct Diseases - drug therapy; Female; Forkhead Transcription Factors - metabolism; Gene Expression Regulation - drug effects; Humans; Interleukin-10 - metabolism; Interleukin-2 - metabolism; Ischemia - diet therapy; Liver Transplantation; Male; Middle Aged; Postoperative Complications - drug therapy; Sirolimus - therapeutic use; Young Adult
• ISSN: 0529-5815

To investigate the pathogenesis of ischemic-type biliary lesions (ITBLs) in post-liver transplant patients and the possible therapeutic mechanisms of sirolimus. The clinic data of 32 post-liver transplant patients with ITBLs from May 2004 to December 2010 was analyzed. There were including 25 male and 7 female patients with a median age of 46 years (ranging from 19 to 61 years). Patients were divided into those who received sirolimus (sirolimus group) and those who did not (control group). The expression of IL-2, FoxP3, and IL-10 in the portal area, liver function indexes, and bile duct injury score were assessed pre-ITBL, when ITBLs were identified, and after 6 months of sirolimus treatment. Compared with pre-ITBL optical density (OD) values, there was a significantly increase in IL-2 OD(0.138 ± 0.050 in control group and 0.141 ± 0.052 in sirolimus group), but not FoxP3 and IL-10 OD in both groups at the time ITBLs were diagnosed. After 6 months of treatment, the IL-2, FoxP3, and IL-10 OD values in the contr