2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm

• Published in: Biochemical journal Vol. 448; no. 2; p. 189
• Main Authors: Lefièvre, Linda, Nash, Katherine, Mansell, Steven, Costello, Sarah, Punt, Emma, Correia, Joao, Morris, Jennifer, Kirkman-Brown, Jackson, Wilson, Stuart M, Barratt, Christopher L R, Publicover, Stephen
• Format: Journal Article
• Language: English
• Published: England 01.12.2012
• Subjects: Boron Compounds - pharmacology; Calcium Channel Agonists - pharmacology; Calcium Channels - metabolism; Calcium Signaling - drug effects; Cell Adhesion Molecules - metabolism; Humans; In Vitro Techniques; Loperamide - pharmacology; Male; Membrane Proteins - metabolism; Neoplasm Proteins - metabolism; ORAI1 Protein; ORAI2 Protein; Progesterone - pharmacology; Sperm Midpiece - drug effects; Sperm Midpiece - metabolism; Sperm Motility - drug effects; Spermatozoa - drug effects; Spermatozoa - metabolism; Stromal Interaction Molecule 1; Stromal Interaction Molecule 2

Ca2+i signalling is pivotal to sperm function. Progesterone, the best-characterized agonist of human sperm Ca2+i signalling, stimulates a biphasic [Ca2+]i rise, comprising a transient and subsequent sustained phase. In accordance with recent reports that progesterone directly activates CatSper, the...