Pharmacokinetic of gabapentin 600 mg tablet in Thai healthy subjects

• Published in: Journal of the Medical Association of Thailand Vol. 95; no. 4; p. 583
• Main Authors: Wittayalertpanya, Supeecha, Chompootaweep, Sumana, Thaworn, Nongnuch, Khemsri, Wondee, Prompila, Nantaporn, Sayankuldilok, Nonlanee, Punyasang, Wasan
• Format: Journal Article
• Language: English
• Published: Thailand 01.04.2012
• Subjects: Administration, Oral; Adult; Amines - administration & dosage; Amines - pharmacokinetics; Anticonvulsants - administration & dosage; Anticonvulsants - pharmacokinetics; Area Under Curve; Biological Availability; Cyclohexanecarboxylic Acids - administration & dosage; Cyclohexanecarboxylic Acids - pharmacokinetics; gamma-Aminobutyric Acid - administration & dosage; gamma-Aminobutyric Acid - pharmacokinetics; Humans; Male; Reference Values; Tablets; Young Adult

Gabapentin is an antiepileptic drug. It is structurally similar to yaminobutyric acid (GABA), which crosses the blood-brain barrier. Gabapentin is absorbed into the blood by the L-amino acid transport system. The oral bioavailability of gabapentin displays dose-dependence. Plasma concentrations ofga...