Polymethoxylated flavonoids activate cystic fibrosis transmembrane conductance regulator chloride channel

• Published in: Sheng li hsüeh pao Vol. 67; no. 2; p. 225
• Main Authors: Cao, Huan-Huan, Fang, Fang, Yu, Bo, Luan, Jian, Jiang, Yu, Yang, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 25.04.2015
• Subjects: Animals; Colforsin; Colon - metabolism; Cystic Fibrosis Transmembrane Conductance Regulator - drug effects; Flavones - physiology; Flavonoids - pharmacology; Genistein; Intestinal Mucosa - metabolism; Mice; Rats

Cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent chloride channel, plays key roles in fluid secretion in serous epithelial cells. Previously, we identified two polymethoxylated flavonoids, 3',4',5,5',6,7-hexamethoxyflavone (HMF) and 5-hydroxy-6,7,3',4&...