Expression and functional SNP loci screen of ATM from coal worker's pneumoconiosis

• Published in: Zhonghua laodong weisheng zhiyebing zazhi Vol. 40; no. 2; p. 103
• Main Authors: Deng, H, Zhang, T, Wu, M L, Yang, G G, Chen, Y, Liang, Y D
• Format: Journal Article
• Language: Chinese
• Published: China 20.02.2022
• Subjects: Anthracosis - epidemiology; Anthracosis - genetics; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins - genetics; China; Coal; Coal Mining; Humans; Miners; Pneumoconiosis - epidemiology; Polymorphism, Single Nucleotide; China; DNA damage repair; Early diagnosis; Gene; Pneumoconiosis; DNA; Ataxia telangiectasia mutated; Coal workers' pneumoconiosis; Single nucleotide polymarphism
• ISSN: 1001-9391
• DOI: 10.3760/cma.j.cn121094-20201019-00590

To detect of gene expression and genotype of the ataxia telangiectasia mutated ( ) from coal workers' pneumoconiosis (CWP) , It is explored whether CWP is related to gene. In October 2020, the relevant information of 264 subjects who received physical examination or medical treatment in the Department of occupational diseases of Guiyang public health treatment center from January 2019 to September 2020 was collected. Through the occupational health examination, 67 healthy people with no history of exposure to occupational hazards were selected as the healthy control group; The coal miners with more than 10 years of coal dust exposure history and small shadow in the lung but not up to the diagnostic criteria were the dust exposure control group, a total of 66 people; The patients with the same history of coal dust exposure and confirmed stage I were coal worker's pneumoconiosis stage I group, a total of 131 people. The expression of was detected by QRT PCR. rs189037 and rs1801516 were genotyped by massarray. T