Association between platelet-activating factor acetylhydrolase gene polymorphism and intracranial hemorrhage in preterm infants

• Published in: Zhongguo dang dai er ke za zhi Vol. 14; no. 8; p. 612
• Main Authors: Zhang, Qian, Cheng, Xin-Ru, Xu, Shu-Ling, Shi, Zan-Yang, Sheng, Guang-Yao
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2012
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics; Female; Humans; Infant, Newborn; Infant, Premature; Intracranial Hemorrhages - etiology; Intracranial Hemorrhages - genetics; Male; Polymorphism, Single Nucleotide
• ISSN: 1008-8830

To explore whether Val279Phe single nucleotide polymorphisms (SNPs) in the 9th exon of platelet-activating factor acetylhydrolase (PAF-AH) are associated with intracranial hemorrhage in preterm infants. A case-control study was performed. Polymerase chain reaction (PCR) was used to test genotype and allele frequencies of the 9th exon Val279Phe SNPs of PAF-AH in 58 preterm infants with intracranial hemorrhage (hemorrhage group) and 65 preterm infants without intracranial hemorrhage (control group). There were significant differences in genotype frequency of Val279Phe SNPs in the 9th exon of PAF-AH between the hemorrhage and control groups (P<0.05). Frequency of normal genotype in the hemorrhage group (63.8%) was significantly lower than in the control group (81.5%). In contrast, frequency of heterozygous genotype (34.5%) in the hemorrhage group was significantly higher than in control group (16.9%). There were also significant differences in allele frequency of Val279Phe SNPs in the 9th exon of PAF-AH between