Ultrasensitive detection of PrP(Sc) in the cerebrospinal fluid and blood of macaques infected with bovine spongiform encephalopathy prion

• Published in: Journal of general virology Vol. 95; no. Pt 11; p. 2576
• Main Authors: Murayama, Yuichi, Masujin, Kentaro, Imamura, Morikazu, Ono, Fumiko, Shibata, Hiroaki, Tobiume, Minoru, Yamamura, Tomoaki, Shimozaki, Noriko, Terao, Keiji, Yamakawa, Yoshio, Sata, Tetsutaro
• Format: Journal Article
• Language: English
• Published: England 01.11.2014
• Subjects: Animals; Cattle; Creutzfeldt-Jakob Syndrome - blood; Creutzfeldt-Jakob Syndrome - cerebrospinal fluid; Disease Models, Animal; Encephalopathy, Bovine Spongiform - blood; Encephalopathy, Bovine Spongiform - cerebrospinal fluid; Humans; Macaca fascicularis - blood; Macaca fascicularis - cerebrospinal fluid; Male; Mice; PrPSc Proteins - blood; PrPSc Proteins - cerebrospinal fluid; Tissue Distribution

Prion diseases are characterized by the prominent accumulation of the misfolded form of a normal cellular protein (PrP(Sc)) in the central nervous system. The pathological features and biochemical properties of PrP(Sc) in macaque monkeys infected with the bovine spongiform encephalopathy (BSE) prion...