Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies

• Published in: Synapse (New York, N.Y.) Vol. 69; no. 12; p. 577
• Main Authors: Mukherjee, Jogeshwar, Constantinescu, Cristian C, Hoang, Angela T, Jerjian, Taleen, Majji, Divya, Pan, Min-Liang
• Format: Journal Article
• Language: English
• Published: United States 01.12.2015
• Subjects: Animals; Benzamides - pharmacokinetics; Brain - diagnostic imaging; Brain - metabolism; Dopamine Agonists - pharmacology; Dopamine Antagonists - pharmacology; Fluorenes - pharmacology; Male; Mice; Mice, Inbred C57BL; Piperazines - pharmacology; Positron-Emission Tomography; Protein Binding; Pyrrolidines - pharmacokinetics; Rabbits; Radiopharmaceuticals - pharmacokinetics; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D3 - agonists; Receptors, Dopamine D3 - antagonists & inhibitors; Receptors, Dopamine D3 - metabolism; Species Specificity; Tetrahydronaphthalenes - pharmacology; Tissue Distribution; 7-OH-DPAT; BP 897; NGB 2904; PET imaging; 18F-fallypride; addiction; dopamine D3 receptors

Identification of dopamine D3 receptors (D3R) in vivo is important to understand several brain functions related to addiction. The goal of this work was to identify D3R binding of the dopamine D2 receptor (D2R)/D3R imaging agent, (18)F-fallypride. Brain slices from male Sprague-Dawley rats (n = 6) a...