Role of anti-nucleosome antibodies in the diagnosis of systemic lupus erythematosus and as a marker for lupus nephropathy

• Published in: The Egyptian journal of immunology Vol. 21; no. 1; p. 57
• Main Authors: Abdel Gawad, Eman R, Mansour, Amira I, Abdel Aziz, Yasser A, Soliman, Aml F, Fawzy, Rasha M
• Format: Journal Article
• Language: English
• Published: Egypt 2014
• Subjects: Adult; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Biomarkers - blood; DNA - immunology; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G - blood; Immunoglobulin G - immunology; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - immunology; Lupus Nephritis - blood; Lupus Nephritis - diagnosis; Lupus Nephritis - immunology; Male; Middle Aged; Nucleosomes - immunology; Sensitivity and Specificity; Young Adult

SLE is a heterogeneous disease, characterized by variation in clinical and serological manifestations. This study intended to verify the role of anti-nucleosome (anti-NCS) antibodies in diagnosis of SLE and lupus nephritis and to establish the correlation between antibody reactivity and disease acti...