The enigma of Henry IV's disease: Did he suffer from McCune-Albright syndrome/fibrous dysplasia?

• Published in: Revista española de patología Vol. 56; no. 4; pp. 243 - 251
• Main Authors: Tuñón Álvarez, M Teresa, Ruiz Calleja, Adolfo, Pérez de Nanclares, Guiomar
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.10.2023
• Subjects: Acromegaly - complications; Acromegaly - genetics; Adenoma; Chromogranins; Fibrous Dysplasia, Polyostotic - complications; Fibrous Dysplasia, Polyostotic - diagnosis; Fibrous Dysplasia, Polyostotic - genetics; Humans; Male; Syndrome; Enrique IV; Fibrous dysplasia; McCune-Albright; GNAS; Henry IV; Trastámara; Displasia fibrosa

Henry IV King of Castile, last king of the Trastámara dynasty, was the brother of Isabella the Catholic. He is known as "the impotent". Based on previous descriptions by historians and biographers, Gregorio Marañón in 1922 described him as "eunuchoid dysplastic with acromegalic reacti...