The Expression and Significance of Serum Protein ROCK2 in Patients with Chronic Graft-Versus-Host Disease

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 29; no. 5; p. 1606
• Main Authors: Tang, Ping, Zheng, Chen-Hui, Dong, Zhen-Kun, Xie, Meng-Han, Xie, Xin-Sheng, Sun, Hui, Sun, Ling, Wan, Ding-Ming, Liu, Yan-Fang, Jiang, Zhong-Xing, Guo, Rong
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2021
• Subjects: Blood Proteins; Chronic Disease; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; rho-Associated Kinases; Transplantation, Homologous
• DOI: 10.19746/j.cnki.issn.1009-2137.2021.05.037
• ISSN: 1009-2137

To investigate the expression and clinical significance of serum protein ROCK2 in patients with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The patients were divided into cGVHD group and control group (without cGVHD). The expression levels of serum protein ROCK2 were detected by ELISA in patients with or without cGVHD after allo-HSCT. The expression level of ROCK2 in serum of cGVHD patients was significantly higher than those in control group, moreover, the expression level of ROCK2 in severe cGVHD group was significant higher than that in moderate and mild cGVHD group (P<0.001). The expression level of ROCK2 was significantly decreased in the serum of cGVHD patients after treatment（P＜0.01）; the expression level of ROCK2 was significantly higher in the serum of cGVHD patients with lung as the target organ（P＜0.01）. The median survival time of patients with severe cGVHD were significantly shorter than that of patients with mild and moderate cGV