Elevated expression of Bmi1 in hepatocellular carcinoma with bile duct tumor thrombi

• Published in: Hepato-gastroenterology Vol. 60; no. 128; p. 2042
• Main Authors: Zhang, Rui, Xu, Lei-Bo, Zeng, Hong, Yu, Xian-Huan, Wang, Jie, Liu, Chao
• Format: Journal Article
• Language: English
• Published: Greece 01.11.2013
• Subjects: Bile Duct Neoplasms - chemistry; Bile Duct Neoplasms - pathology; Bile Ducts, Intrahepatic - chemistry; Bile Ducts, Intrahepatic - pathology; Biomarkers, Tumor - analysis; Biopsy; Carcinoma, Hepatocellular - chemistry; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cholangiocarcinoma - chemistry; Cholangiocarcinoma - pathology; Female; Humans; Immunohistochemistry; Liver Neoplasms - chemistry; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; Middle Aged; Mucin-1 - analysis; Neoplasm Invasiveness; Polycomb Repressive Complex 1 - analysis; Polycomb Repressive Complex 1 - genetics; Real-Time Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Up-Regulation

Hepatocellular carcinoma (HCC) with bile duct tumor thrombi (BDTT) is a rare event. The Bmi1 gene has been reported to play important roles in cancer initiation and progression. In this study, the expression of Bmi1 in HCC with BDTT was investigated. The expression of Bmi1 was examined immunohistoch...