Clinicopathologic and molecular characteristics of myxoid angiomatoid fibrous histiocytoma

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 42; no. 1; pp. 37 - 43
• Main Authors: Zhao, M, Yu, L L, Xu, M X, Zhang, X, He, X L, Ru, G Q
• Format: Journal Article
• Language: Chinese
• Published: China 23.01.2020
• Subjects: Adult; Female; Gene Rearrangement; Histiocytoma, Benign Fibrous - diagnosis; Histiocytoma, Benign Fibrous - genetics; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Male; Neoplasm Recurrence, Local; Myxoid; Soft tissue; Fibrous histiocytoma; Sarcoma; EWSR1; Angiomatoid
• ISSN: 0253-3766
• DOI: 10.3760/cma.j.issn.0253-3766.2020.01.005

To investigate the molecular genetic and clinicopathologic characteristics, immunophenotypes, diagnostic and differential diagnostic features of myxoid angiomatoid fibrous histiocytoma (MAFH). Three cases of MAFH were collected from the archives of Zhejiang Provincial People's Hospital between January 2015 to August 2018. The clinical and radiologic features, histomorphology, immunohistochemistry, molecular genetics and prognosis were analyzed. Patients consisted of 2 women and 1 man aged 37 years, 46 years, and 57 years, respectively. The clinical manifestations of 3 patients were presented as a painless, slowly-enlarged mass with a duration ranging of 2 weeks, 2 months and 50 years. These tumors were located at the deep somatic soft tissue of extremities or limbs (right hip, left forearm, left wrist, respectively) and 2 were preoperatively considered as ganglion cyst or giant cell tumor of tendon sheath by imaging examinations. The diameter of circumscribed mass lesion was ranged from 3.0 to 7.5 cm, which e