Effect of Yuyin Ruangan Granule on TGF-β1 expression in hepatic fibrosis rats

• Published in: Zhongguo ying yong sheng li xue za zhi Vol. 34; no. 2; p. 169
• Main Authors: Wang, Zhi-Wang, Fu, Xiao-Yan, Cheng, Xiao-Li, Bao, Xiao-Ying, Liu, Xue-Feng, Duan, Hai-Jing
• Format: Journal Article
• Language: Chinese
• Published: China 08.02.2018
• Subjects: Animals; Carbon Tetrachloride; Drugs, Chinese Herbal - pharmacology; Liver - drug effects; Liver - metabolism; Liver Cirrhosis - chemically induced; Liver Cirrhosis - drug therapy; Liver Cirrhosis - metabolism; Random Allocation; Rats; Rats, Wistar; Transforming Growth Factor beta1 - metabolism; Yuyin Ruangan Granule (YRG); carbon tetrachloride; rat; hepatic fibrosis; β1-transformating growth factor (TGF-β1)
• ISSN: 1000-6834
• DOI: 10.12047/j.cjap.5593.2018.041

To observe the preventive and therapeutic action of Yuyin Ruangan Granule (YRG, Traditional Chinese Medicine) in hepatic fibrosis rats model and its effect on transforming growth factor-β1 (TGF-β1) expression. The Wistar rats were randomly divided into 6 group ( =10), and the model of hepatic fibrosis rats was established by subcutaneous injected with carbon tetrachloride (CCL4), fed on high-fat diet and 20% ethanol for 6 weeks, to survey the effect and mechanism of YRG preventing hypatic fibrosis by detecting liver function (the activity of alanine aminotransferase(ALT), aspartate aminotransferase(AST), etc.) of liver fibrosis rats, liver fibrosis indicators (hyaluronic acid, Ⅲ procollagen, type IV collagen, laminin and hepatic pathology, etc.), and TGF-β1 expression in liver tissue after 6 weeks treated with YRG through intragastric administration (q. d.). At the 7 week, fibrotic lesions appears distinctly in liver tissue of model group compared with control group ( <0.01), YRG of 6.2~28.8 g/kg could signif