Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia

• Published in: British journal of haematology Vol. 150; no. 2; p. 218
• Main Authors: Nouraie, Mehdi, Reading, Noel S, Campbell, Andrew, Minniti, Caterina P, Rana, Sohail R, Luchtman-Jones, Lori, Kato, Gregory J, Gladwin, Mark T, Castro, Oswaldo L, Prchal, Josef T, Gordeuk, Victor R
• Format: Journal Article
• Language: English
• Published: England 01.07.2010
• Subjects: Adolescent; Alleles; alpha-Thalassemia - blood; Anemia, Sickle Cell - blood; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - genetics; Antisickling Agents - therapeutic use; Child; Child, Preschool; Female; Genotype; Glucosephosphate Dehydrogenase - genetics; Glucosephosphate Dehydrogenase Deficiency - blood; Glucosephosphate Dehydrogenase Deficiency - complications; Glucosephosphate Dehydrogenase Deficiency - genetics; Hemoglobins - analysis; Hemolysis - genetics; Humans; Hydroxyurea - therapeutic use; Male; Phenotype; Young Adult

The genetic bases of the highly variable degrees of anaemia and haemolysis in persons with Hb SS are not fully known, but several studies have indicated that G6PD deficiency is not a factor. The G6PD(202A) and G6PD(376G) alleles and alpha-thalassaemia were determined by molecular genetic testing in...