Evaluation of matrix metalloproteinases (pro-MMP-1, MMP-2,8) and their inhibitor (TIMP-1) contents in patients with occupational lung diseases

Studies of matrix metalloproteinases in patients with occupational bronchopulmonary diseases and in individuals exposed to asbestos dust revealed hyperactivated protease system--lower level of MMP-1 proenzyme and increased production of TIMP-1 (metalloproteinases inhibitor)--in all the examinees gro...

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Bibliographic Details
Published inMeditsina truda i promyshlennaia ekologiia no. 7; p. 29
Main Authors Fomina, V S, Kuz'mina, L P
Format Journal Article
LanguageRussian
Published Russia (Federation) 2010
Subjects
Asbestos - toxicity
Asthma - enzymology
Asthma - etiology
Biomarkers - metabolism
Bronchial Diseases - enzymology
Bronchial Diseases - etiology
Bronchitis - enzymology
Bronchitis - etiology
Dust
Environmental Pollutants - toxicity
Enzyme Activation
Female
Humans
Lung Diseases - enzymology
Lung Diseases - etiology
Male
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 8 - metabolism
Occupational Diseases - enzymology
Occupational Diseases - etiology
Pneumoconiosis - enzymology
Pneumoconiosis - etiology
Protein Precursors - metabolism
Tissue Inhibitor of Metalloproteinase-1 - metabolism
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Summary:Studies of matrix metalloproteinases in patients with occupational bronchopulmonary diseases and in individuals exposed to asbestos dust revealed hyperactivated protease system--lower level of MMP-1 proenzyme and increased production of TIMP-1 (metalloproteinases inhibitor)--in all the examinees groups. Patients with pneumoconiosis and occupational dust bronchitis demonstrated increased neutrophilic elastase that is activator of metalloproteinases inducing sclerotic changes and pulmonary fibrosis.
ISSN:1026-9428