Clinical application of prefilled pen and conventional syringe during controlled ovarian stimulation for in vitro fertilization

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 29; no. 1; p. 100
• Main Authors: Chen, Lei-ning, Quan, Song, Li, Hong, Yang, Xiao-ping, Chen, Si-mei, Zhang, Xiao-yu, Lin, Lei, Xing, Fu-qi, Chen, Shi-ling, Wan, Zhao-jun, Wang, Yi
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2009
• Subjects: Adult; Embryo Transfer; Female; Fertilization in Vitro - methods; Follicle Stimulating Hormone - administration & dosage; Humans; Infertility, Female - therapy; Ovulation Induction - instrumentation; Ovulation Induction - methods; Recombinant Proteins - administration & dosage
• ISSN: 1673-4254

To investigate the efficacy, convenience and costs of recombinant follitropin alpha administered by a prefilled pen device and conventional syringe in Chinese women undergoing controlled ovarian stimulation for in vitro fertilization (IVF). A total of 184 patients undergoing IVF treatment were enrolled in this study. According to a long-term recombinant follicle-stimulating hormone (rFSH) protocol, ovarian stimulation was performed with the prefilled pen and conventional syringe at random in these subjects, and the dose of follitropin, number of oocytes and embryo parameters and IVF-ET outcome were compared between the two groups. The total rFSH dose, cost, and frequency of hospital visits were significantly lower in the pen protocol group, but the residual rFSH amount was higher. Compared with conventional injections, the prefilled pen was associated with significantly lowered rate of local redness, high rate of local bruise, more frequent follitropin dose modulation and lower serum oestradiol levels on HCG