Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness

To investigate the relationship between heat stress proteins 70 (HSPs70) gene polymorphism and the risk of acute mountain sickness. Fifty-six soldiers with acute mountain sickness and 173 soldiers without that were chosen as cases and controls. HSP70-1, HSP70-2 genotypes were analyzed by using the p...

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Published inZhonghua laodong weisheng zhiyebing zazhi Vol. 22; no. 6; p. 413
Main Authors Li, Fang-Ze, Zhou, Fang, Jiang, Chang-Zheng, Sun, Su-Yong, He, Mei-An, Zhang, Shu-Yu, Liao, Rong, Zeng, Hua-Song, Wu, Yi-Ming, Wu, Tang-Chun
Format Journal Article
LanguageChinese
Published China 01.12.2004
Subjects
Acute Disease
Adolescent
Adult
Altitude
Altitude Sickness - epidemiology
Altitude Sickness - genetics
Genotype
HSP70 Heat-Shock Proteins - genetics
Humans
Male
Polymorphism, Genetic
Young Adult
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Summary:To investigate the relationship between heat stress proteins 70 (HSPs70) gene polymorphism and the risk of acute mountain sickness. Fifty-six soldiers with acute mountain sickness and 173 soldiers without that were chosen as cases and controls. HSP70-1, HSP70-2 genotypes were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The HSP70-1 polymorphism was similar in two groups. The genotype frequency of HSP70-2 B/B in acute mountain sickness group (23.2%) was significantly higher than that in the control (6.9%, P < 0.05, OR = 4.02). There is a significantly increased association of HSP70-2 B/B genotype with the risk of acute mountain sickness. Individuals with HSP70-2 B/B genotype may have weaker adaptive ability than those without this genotype under altitude stress. The results contribute to provide scientific bases for finding these individuals in specified occupational people, ensuring their health and enhancing work efficiency.
ISSN:1001-9391