Thymosin β4 expression correlates with lymph node metastasis through hypoxia inducible factor-α induction in breast cancer

• Published in: Oncology reports Vol. 25; no. 1; pp. 23 - 31
• Main Authors: Yoon, Sun Young, Lee, Ha Reum, Park, Yoorim, Kim, Joo Heon, Kim, Soo Young, Yoon, Suk Ran, Lee, Wang Jae, Cho, Byung Joo, Min, Hyeyoung, Bang, Jung-Wook, Park, Hyunjeong, Bang, Sa Ik, Cho, Daeho
• Format: Journal Article
• Language: English
• Published: Greece 01.01.2011
• Subjects: Basic Helix-Loop-Helix Transcription Factors - biosynthesis; Biomarkers, Tumor - analysis; Blotting, Western; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Hypoxia - physiology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Thymosin - biosynthesis

Intratumoral hypoxia has been correlated with distant metastatic potential. Two hypoxia inducible factors (HIFs), HIF-1α and HIF-2α, are induced by hypoxia, and high expression of these proteins has been correlated to angiogenesis and distant metastasis. Thymosin β4 (Tβ4) is frequently highly expres...