Advances in the quantitative analytical methods of drug polymorphism

• Published in: Yao hsüeh hsüeh pao Vol. 46; no. 8; p. 896
• Main Authors: Ma, Le-Wei, Du, Wei, Zhao, Chun-Shun
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2011
• Subjects: Calorimetry, Differential Scanning - methods; Chemistry, Pharmaceutical - methods; Crystallization; Fourier Analysis; Magnetic Resonance Spectroscopy - methods; Pharmaceutical Preparations - chemistry; Spectroscopy, Fourier Transform Infrared - methods; Spectroscopy, Near-Infrared - methods; Spectrum Analysis, Raman - methods; Technology, Pharmaceutical - methods; Terahertz Spectroscopy - methods; X-Ray Diffraction - methods

Polymorphism of drug is known to influence the stability, dissolution, bioavailability and other performance characteristics of the products. Therefore, the crystal form of the drug must be identified and determined in order to ensure consistent product performance. Even if the identification and ch...