A retrospective analysis of neurotoxicity induced by vinca alkaloids combined with azole anti-fungal agents in hematological malignancies

• Published in: Gan to kagaku ryoho Vol. 38; no. 10; p. 1667
• Main Authors: Osato, Yoichi, Yokoyama, Tomohisa, Saito, Yumiko, Kani, Rinako, Hayabe, Hiroko, Miyamatsu, Hironobu, Ohyashiki, Kazuma
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.10.2011
• Subjects: Adult; Aged; Aged, 80 and over; Antifungal Agents - administration & dosage; Antifungal Agents - adverse effects; Antifungal Agents - therapeutic use; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Azoles - administration & dosage; Azoles - adverse effects; Azoles - therapeutic use; Female; Hematologic Neoplasms - drug therapy; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Retrospective Studies; Vinca Alkaloids - administration & dosage; Vinca Alkaloids - adverse effects; Vinca Alkaloids - therapeutic use; Young Adult

Vinca alkaloids (VA) are some of the key anti-tumor agents for patients with hematological malignancies, and various adverse events such as paralytic ileus, peripheral neuropathy, and constipation were now recognized as adverse VA effects. Furthermore, azole anti-fungal agents are known to enhance V...