Isolation and characterization of Hainantoxin-II, a new neurotoxic peptide from the Chinese bird spider (Haplopelma hainanum)

• Published in: Dōngwùxué yánjiū Vol. 31; no. 6; p. 570
• Main Authors: Pan, Jian-Yi, Yu, Zhi-Qiang
• Format: Journal Article
• Language: English
• Published: China 01.12.2010
• Subjects: Amino Acid Sequence; Animals; Cockroaches; Male; Mice; Molecular Sequence Data; Neurotoxins - chemistry; Neurotoxins - isolation & purification; Neurotoxins - toxicity; Spider Venoms - chemistry

Hainantoxin-II (HnTx-II), a novel neurotoxin, was isolated from the venom of the Chinese bird spider (Haplopelma hainanum) by cation exchange chromatography and reverse-phase HPLC. The toxin was a single chain polypeptide with calculated molecular weight of 4 253.135 obtained by mass spectrometry. T...