Expression and significance of basic fibroblast growth factor and transforming growth factor-beta 1 in mucoepidermoid carcinoma with different malignant degree

• Published in: Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 40; no. 5; p. 881
• Main Authors: Cao, Yu-Tang, Zhao, Dan, Yang, Sen, Wang, Xiao-Yi, Gao, Qing-Hong, Xuan, Ming, Cao, Jing-Fang
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2009
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Mucoepidermoid - metabolism; Carcinoma, Mucoepidermoid - pathology; Child; Female; Fibroblast Growth Factor 2 - genetics; Fibroblast Growth Factor 2 - metabolism; Humans; Male; Middle Aged; Salivary Gland Neoplasms - metabolism; Salivary Gland Neoplasms - pathology; Salivary Glands - metabolism; Salivary Glands - pathology; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Young Adult
• ISSN: 1672-173X

To study the expression and significance of basic fibroblast growth factor(bFGF)and transforming growth factor-beta 1 (TGF-beta1) in mucoepidermoid carcinomas with different malignant degree. Using immunohistochemistry (IHC) staining technique, bFGF and TGF-beta1 proteins in the mucoepidermoid carcinoma tissues with different malignant degree, including well-differentiated, moderately differentiated and poorly differentiated mucoepidermoid carcinoma, and normal salivary gland tissue were detected. The positive rate of bFGF and TGF-beta1 in normal salivary glands were apparently lower than those in malignant mucoepidermoid carcinomas (P<0.05). The positive rate of bFGF in moderately and poorly differentiated mucoepidermoid carcinoma was higher than that in the well-differentiated carcinoma (P <0.05). However, the positive expression of bFGF showed no relationship between the moderately and poorly differentiated mucoepidermoid carcinomas. The positive rate of TGF-beta1 in moderately and poorly differentiated mu