The allele (A)-110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women

• Published in: Biogerontology (Dordrecht) Vol. 4; no. 4; pp. 215 - 220
• Main Authors: ALTOMARE, K, GRECO, V, PASSARINO, G, FRANCESCHI, C, DE BENEDICTIS, G, BELLIZZI, D, BERARDELLI, M, DATO, S, DERANGO, F, GARASTO, S, ROSE, G, FERACO, E, MARI, V
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.08.2003; Springer Nature B.V
• Subjects: Ageing, cell death; Biological and medical sciences; Cell physiology; Confidence intervals; Fundamental and applied biological sciences. Psychology; Molecular and cellular biology; Human; Allele; Genetic variability; Ageing; Heat shock protein; Female; Genotype; Inflammation; Longevity; Polymorphism

Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with stress is believed to affect the chance of health and survival at organismal level. We have investigated whether the gene pool relevant to the (...