Temporal changes in renal glomerular function associated with the use of Tenofovir Disoproxil Fumarate in HIV-infected Nigerians

• Published in: West African journal of medicine Vol. 30; no. 3; pp. 164 - 168
• Main Authors: Agbaji, O O, Agaba, P A, Idoko, J A, Taiwo, B, Murphy, R, Kanki, P, Ekong, E
• Format: Journal Article
• Language: English
• Published: Nigeria 01.05.2011
• Subjects: Adenine - adverse effects; Adenine - analogs & derivatives; Adult; Aged; Anti-HIV Agents - adverse effects; Antiretroviral Therapy, Highly Active; Creatinine - blood; Female; Glomerular Filtration Rate - drug effects; HIV Infections - drug therapy; HIV Infections - physiopathology; HIV-1; Hospitals, Teaching; Humans; Male; Middle Aged; Nigeria; Organophosphonates - adverse effects; Retrospective Studies; Reverse Transcriptase Inhibitors - adverse effects; Tenofovir; Nigeria

Reports of renal dysfunction in Tenofovir Disoproxil Fumarate (TDF)-treated HIV-1 infected patients have raised concerns about potential nephrotoxicity. To compare the effects on renal function of TDF-containing highly active anti-retroviral therapy (HAART) with a non-TDF-containing HAART. This was...