A case of advanced gastric cancer responding to paclitaxel/CDDP neoadjuvant chemotherapy leading to pathologically complete response

• Published in: Gan to kagaku ryoho Vol. 35; no. 8; p. 1383
• Main Authors: Sakon, Masahiro, Sekino, Yasushi, Okita, Kouichi, Kusama, Kei, Seki, Hitoshi, Munakata, Yasuhiro, Hosaka, Noriko, Mikami, Kazuhisa
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.08.2008
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cisplatin - therapeutic use; Endoscopes, Gastrointestinal; Gastrectomy; Humans; Male; Neoadjuvant Therapy; Neoplasm Staging; Paclitaxel - therapeutic use; Stomach Neoplasms - diagnostic imaging; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Tomography, X-Ray Computed
• ISSN: 0385-0684

A 74-year-old male with advanced gastric cancer(cT3N1M0H0P0CY0, cStage III A)was treated with paclitaxel/ CDDP as neoadjuvant chemotherapy. Paclitaxel (80 mg/m(2)) and CDDP (25 mg/m(2)) were administered on days 1, 8 and 15 as one cycle. After the second course, a significant tumor reduction was obtained. Total gastrectomy, splenectomy, and D2 type nodal dissection were performed. The histological diagnosis revealed complete disappearance of cancer cells in the stomach and all of the lymph nodes, a so-called pathologically complete response. The patient has now been in good health without any recurrence for 9 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/CDDP is a potential regimen for advanced gastric cancer.