A case of advanced gastric cancer responding to paclitaxel/CDDP neoadjuvant chemotherapy leading to pathologically complete response
A 74-year-old male with advanced gastric cancer(cT3N1M0H0P0CY0, cStage III A)was treated with paclitaxel/ CDDP as neoadjuvant chemotherapy. Paclitaxel (80 mg/m(2)) and CDDP (25 mg/m(2)) were administered on days 1, 8 and 15 as one cycle. After the second course, a significant tumor reduction was obt...
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Published in | Gan to kagaku ryoho Vol. 35; no. 8; p. 1383 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | Japanese |
Published |
Japan
01.08.2008
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Abstract | A 74-year-old male with advanced gastric cancer(cT3N1M0H0P0CY0, cStage III A)was treated with paclitaxel/ CDDP as neoadjuvant chemotherapy. Paclitaxel (80 mg/m(2)) and CDDP (25 mg/m(2)) were administered on days 1, 8 and 15 as one cycle. After the second course, a significant tumor reduction was obtained. Total gastrectomy, splenectomy, and D2 type nodal dissection were performed. The histological diagnosis revealed complete disappearance of cancer cells in the stomach and all of the lymph nodes, a so-called pathologically complete response. The patient has now been in good health without any recurrence for 9 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/CDDP is a potential regimen for advanced gastric cancer. |
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AbstractList | A 74-year-old male with advanced gastric cancer(cT3N1M0H0P0CY0, cStage III A)was treated with paclitaxel/ CDDP as neoadjuvant chemotherapy. Paclitaxel (80 mg/m(2)) and CDDP (25 mg/m(2)) were administered on days 1, 8 and 15 as one cycle. After the second course, a significant tumor reduction was obtained. Total gastrectomy, splenectomy, and D2 type nodal dissection were performed. The histological diagnosis revealed complete disappearance of cancer cells in the stomach and all of the lymph nodes, a so-called pathologically complete response. The patient has now been in good health without any recurrence for 9 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/CDDP is a potential regimen for advanced gastric cancer. |
Author | Okita, Kouichi Seki, Hitoshi Sekino, Yasushi Sakon, Masahiro Kusama, Kei Hosaka, Noriko Mikami, Kazuhisa Munakata, Yasuhiro |
Author_xml | – sequence: 1 givenname: Masahiro surname: Sakon fullname: Sakon, Masahiro organization: Dept. of Surgery, Nagano Municipal Hospital – sequence: 2 givenname: Yasushi surname: Sekino fullname: Sekino, Yasushi – sequence: 3 givenname: Kouichi surname: Okita fullname: Okita, Kouichi – sequence: 4 givenname: Kei surname: Kusama fullname: Kusama, Kei – sequence: 5 givenname: Hitoshi surname: Seki fullname: Seki, Hitoshi – sequence: 6 givenname: Yasuhiro surname: Munakata fullname: Munakata, Yasuhiro – sequence: 7 givenname: Noriko surname: Hosaka fullname: Hosaka, Noriko – sequence: 8 givenname: Kazuhisa surname: Mikami fullname: Mikami, Kazuhisa |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18701854$$D View this record in MEDLINE/PubMed |
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Snippet | A 74-year-old male with advanced gastric cancer(cT3N1M0H0P0CY0, cStage III A)was treated with paclitaxel/ CDDP as neoadjuvant chemotherapy. Paclitaxel (80... |
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SubjectTerms | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cisplatin - therapeutic use Endoscopes, Gastrointestinal Gastrectomy Humans Male Neoadjuvant Therapy Neoplasm Staging Paclitaxel - therapeutic use Stomach Neoplasms - diagnostic imaging Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Stomach Neoplasms - surgery Tomography, X-Ray Computed |
Title | A case of advanced gastric cancer responding to paclitaxel/CDDP neoadjuvant chemotherapy leading to pathologically complete response |
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