The protective effects on allografts of adeno-associated heme-oxygenase-1 gene therapy against chronic rejection injury

• Published in: Chung-hua wai kʿo tsa chih Vol. 45; no. 4; p. 254
• Main Authors: Gong, Nian-Qiao, Du, Dun-Feng, Dong, Chong, Chen, Xi-Lin, Guo, Hui, Xiao, Jian-Sheng, Zhang, Wei-Jie, Lin, Zheng-Bin, Chen, Zhi-Shui, Ye, Qi-Fa, Xia, Sui-Sheng
• Format: Journal Article
• Language: Chinese
• Published: China 15.02.2007
• Subjects: Adenoviridae - genetics; Animals; Blood Vessels - transplantation; CD4 Lymphocyte Count; Chronic Disease; Genetic Therapy - methods; Genetic Vectors; Graft Rejection - etiology; Graft Rejection - prevention & control; Graft Survival; Heme Oxygenase-1 - genetics; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Macrophages - pathology; Male; Rats; Rats, Inbred Lew; Transfection; Transplantation, Homologous

To investigate the protective effects on allografts and the possible mechanism of adeno-associated heme-oxygenase-1 (AdHO-1) gene therapy against chronic rejection injury. Ex vivo AdHO-1 gene therapy was performed in vascular and renal transplantation models. The structure and function, the expressi...