The effects of calmodulin kinase II inhibitor on ventricular arrhythmias in rabbits with cardiac hypertrophy

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 35; no. 1; p. 33
• Main Authors: Ke, Jun, Zhang, Cun-tai, Ma, Ye-xin, Liu, Jun, Zhang, Qing-yang, Liu, Nian, Ruan, Yan-fei, Lin, Li
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2007
• Subjects: Animals; Arrhythmias, Cardiac - complications; Arrhythmias, Cardiac - drug therapy; Benzylamines - pharmacology; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors; Cardiomegaly - complications; Cardiomegaly - drug therapy; Disease Models, Animal; Male; Protein Kinase Inhibitors - pharmacology; Rabbits; Sulfonamides - pharmacology

To investigate the effect of KN-93, a calmodulin kinase II inhibitor, on ventricular arrhythmias in rabbits with cardiac hypertrophy. Female New Zealand white rabbits were randomly divided into four groups (n = 10 each): Sham; LVH; LVH + KN-92 and LVH + KN-93 group. LVH was induced by partially cons...