Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing

• Published in: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) Vol. 25; no. 10 Suppl 1; p. 21
• Main Authors: Barlow, Ashley P, Zhou, Xiaojie, Barnes, John E, Hoke, Steve H, Eichhold, Thomas H, Gibb, Roger D, Ramji, Nivedita B, He, Tao, Hunt, Sheri A, Kowolik, Michael J, Somogyi-Mann, Marta
• Format: Magazine Article
• Language: English
• Published: United States 01.10.2004
• Subjects: Adult; Analysis of Variance; Colony Count, Microbial; Cross-Over Studies; Dental Devices, Home Care; Female; Gingival Crevicular Fluid - metabolism; Gingival Crevicular Fluid - microbiology; Gram-Negative Anaerobic Bacteria - drug effects; Humans; Linear Models; Male; Silicic Acid; Single-Blind Method; Sodium Dodecyl Sulfate - analysis; Sodium Fluoride - administration & dosage; Sodium Fluoride - pharmacokinetics; Sodium Fluoride - pharmacology; Sonication; Surface-Active Agents - analysis; Toothbrushing - instrumentation; Toothpastes - administration & dosage; Toothpastes - pharmacokinetics; Toothpastes - pharmacology

The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from...