Influence of ABC-transporters on intracellular distribution of anticancer drugs and contribution of this index to multidrug resistance phenotype

• Published in: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 50; no. 2-3; p. 22
• Main Authors: Ravcheeva, A B, Bogush, E A, Bogush, T A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2005
• Subjects: Animals; Antineoplastic Agents - metabolism; ATP-Binding Cassette Transporters - physiology; Cell Nucleus - metabolism; Cytoplasm - metabolism; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Phenotype

A review of the literature on intracellular accumulation and distribution of anticancer drugs in sensitive and resistant tumor cells with the classic mechanism of multidrug resistance development, as well as on the role of ABC-transporters in the processes is presented. According to the data discuss...