Long-term potentiation and cognitive drug discovery

• Published in: Current opinion in investigational drugs (London, England : 2000) Vol. 6; no. 1; p. 25
• Main Authors: Cooke, Sam F, Bliss, Tim V P
• Format: Journal Article
• Language: English
• Published: England 01.01.2005
• Subjects: Cognition - drug effects; Cognition Disorders - drug therapy; Cognition Disorders - metabolism; Cognition Disorders - physiopathology; CREB-Binding Protein; Cyclic AMP - metabolism; Drug Design; Humans; Long-Term Potentiation - drug effects; Memory - drug effects; Molecular Structure; Neuronal Plasticity - drug effects; Nootropic Agents - chemistry; Nootropic Agents - therapeutic use; Nuclear Proteins - metabolism; Receptors, AMPA - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Trans-Activators - metabolism

Long-term potentiation (LTP) is the activity-dependent process by which transmission is persistently enhanced at chemical synapses in the brain. Details of the cellular mechanisms responsible for LTP are becoming clearer, as neuroscientists identify the key molecules in synaptic transmission, and al...