Long-term potentiation and cognitive drug discovery

Long-term potentiation (LTP) is the activity-dependent process by which transmission is persistently enhanced at chemical synapses in the brain. Details of the cellular mechanisms responsible for LTP are becoming clearer, as neuroscientists identify the key molecules in synaptic transmission, and al...

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Bibliographic Details
Published inCurrent opinion in investigational drugs (London, England : 2000) Vol. 6; no. 1; p. 25
Main Authors Cooke, Sam F, Bliss, Tim V P
Format Journal Article
LanguageEnglish
Published England 01.01.2005
Subjects
Cognition - drug effects
Cognition Disorders - drug therapy
Cognition Disorders - metabolism
Cognition Disorders - physiopathology
CREB-Binding Protein
Cyclic AMP - metabolism
Drug Design
Humans
Long-Term Potentiation - drug effects
Memory - drug effects
Molecular Structure
Neuronal Plasticity - drug effects
Nootropic Agents - chemistry
Nootropic Agents - therapeutic use
Nuclear Proteins - metabolism
Receptors, AMPA - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Trans-Activators - metabolism
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Summary:Long-term potentiation (LTP) is the activity-dependent process by which transmission is persistently enhanced at chemical synapses in the brain. Details of the cellular mechanisms responsible for LTP are becoming clearer, as neuroscientists identify the key molecules in synaptic transmission, and also the signaling cascades, transcription factors and effector molecules that alter transmission at potentiated synapses. In this review we describe the contributions of pharmacology to the field of synaptic plasticity, and also discuss the role of LTP in developing potential nootropic drugs to enhance learning and memory.
ISSN:1472-4472