Influence of integrin-binding motif (RGD) on attachment and internalization of avian adenovirus CELO in mammalian cells
Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency...
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Published in | Molekulârnaâ genetika, mikrobiologiâ i virusologiâ no. 2; p. 32 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Russian |
Published |
Russia (Federation)
2008
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Abstract | Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells. |
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AbstractList | Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells. |
Author | Logunov, D Iu Shmarov, M M Belousova, R V Zubkova, O V Karpov, A P Naroditskiĭ, B S |
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Snippet | Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that... |
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SubjectTerms | Adenoviridae Infections - virology Animals Antigens, Viral - genetics Aviadenovirus - physiology Capsid Proteins - genetics Cell Line, Tumor Coxsackie and Adenovirus Receptor-Like Membrane Protein Genetic Vectors - physiology Humans Integrin alphaV - metabolism Oligopeptides - physiology Reassortant Viruses - physiology Receptors, Virus - deficiency Recombination, Genetic Transduction, Genetic Virus Replication |
Title | Influence of integrin-binding motif (RGD) on attachment and internalization of avian adenovirus CELO in mammalian cells |
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