Influence of integrin-binding motif (RGD) on attachment and internalization of avian adenovirus CELO in mammalian cells

Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency...

Full description

Saved in:
Bibliographic Details
Published inMolekulârnaâ genetika, mikrobiologiâ i virusologiâ no. 2; p. 32
Main Authors Zubkova, O V, Logunov, D Iu, Karpov, A P, Shmarov, M M, Belousova, R V, Naroditskiĭ, B S
Format Journal Article
LanguageRussian
Published Russia (Federation) 2008
Subjects
Adenoviridae Infections - virology
Animals
Antigens, Viral - genetics
Aviadenovirus - physiology
Capsid Proteins - genetics
Cell Line, Tumor
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Genetic Vectors - physiology
Humans
Integrin alphaV - metabolism
Oligopeptides - physiology
Reassortant Viruses - physiology
Receptors, Virus - deficiency
Recombination, Genetic
Transduction, Genetic
Virus Replication
Online AccessGet more information

Cover

More Information
Summary:Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells.
ISSN:0208-0613