Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy

To observe the change of urinary monocyte chemottractant protein-1 (MCP-1) in patients with diabetic nephropathy (DN), and to explore the therapeutic effect and mechanism of triptolide (TL) in treating DN. Thirty-five patients in the treated group were treated with TL plus benazepril and thirty two...

Full description

Saved in:
Bibliographic Details
Published inZhongguo Zhong xi yi jie he za zhi Vol. 25; no. 5; p. 416
Main Authors Song, Hai-xiang, Gong, Jing, Chen, Wen
Format Journal Article
LanguageChinese
Published China 01.05.2005
Subjects
Adult
Aged
Chemokine CCL2 - urine
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - urine
Diterpenes - therapeutic use
Epoxy Compounds
Female
Humans
Immunosuppressive Agents - therapeutic use
Male
Middle Aged
Phenanthrenes - therapeutic use
Phytotherapy
Prospective Studies
Online AccessGet more information
ISSN1003-5370

Cover

Abstract To observe the change of urinary monocyte chemottractant protein-1 (MCP-1) in patients with diabetic nephropathy (DN), and to explore the therapeutic effect and mechanism of triptolide (TL) in treating DN. Thirty-five patients in the treated group were treated with TL plus benazepril and thirty two patients in the control group were treated with benazepril alone for six months. The change of urinary MCP-1 was measured before and after treatment. Level of urinary MCP-1 in DN patients was significantly higher than that in healthy subjects (P < 0.01), but it could be significantly decreased after TL treatment, showing significant difference as compared with that in the control group (P < 0.05). Determination of urinary MCP-1 level is beneficial to know the degree of kidney inflammation in DN patients. TL can inhibit inflammatory reaction to decrease the level of urinary MCP-1, and thus improve the renal function.
AbstractList To observe the change of urinary monocyte chemottractant protein-1 (MCP-1) in patients with diabetic nephropathy (DN), and to explore the therapeutic effect and mechanism of triptolide (TL) in treating DN. Thirty-five patients in the treated group were treated with TL plus benazepril and thirty two patients in the control group were treated with benazepril alone for six months. The change of urinary MCP-1 was measured before and after treatment. Level of urinary MCP-1 in DN patients was significantly higher than that in healthy subjects (P < 0.01), but it could be significantly decreased after TL treatment, showing significant difference as compared with that in the control group (P < 0.05). Determination of urinary MCP-1 level is beneficial to know the degree of kidney inflammation in DN patients. TL can inhibit inflammatory reaction to decrease the level of urinary MCP-1, and thus improve the renal function.
Author Gong, Jing
Song, Hai-xiang
Chen, Wen
Author_xml – sequence: 1
  givenname: Hai-xiang
  surname: Song
  fullname: Song, Hai-xiang
  organization: Linyi Municipal Hospital of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong
– sequence: 2
  givenname: Jing
  surname: Gong
  fullname: Gong, Jing
– sequence: 3
  givenname: Wen
  surname: Chen
  fullname: Chen, Wen
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15957833$$D View this record in MEDLINE/PubMed
BookMark eNo1j0tqwzAUALVIadI0Vyi6gOFJsmxrWUL6gUA27TpI9lMtiCUhv1B8-wbarmYxMDAPbBVTxBXbCABVadXCmu3mOTiADoxswNyztdBGt51SG_Z18B574slzKiFTuoQBeYr8WkK0ZeFTiqlfCHk_4pSIiu3JRuK5JMIQK8FD5NlSwEgz_w408iFYhxR6HjGPJd3kuDyyO28vM-7-uGWfL4eP_Vt1PL2-75-PVRaypsq1VnSmlV4YB7J2Q9N6tE2rJICVncBOeg0gtK-V1cr1csCmrhsF3mgDg9yyp99uvroJh3MuYbptnP-P5Q8_AlVp
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
ExternalDocumentID 15957833
Genre Clinical Trial
Randomized Controlled Trial
English Abstract
Journal Article
GroupedDBID -05
2B.
5XA
5XF
92F
92I
ABJNI
ACGFS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CGR
CIEJG
CUY
CVF
CW9
ECM
EIF
NPM
TCJ
TGQ
U1G
U5O
ID FETCH-LOGICAL-p124t-b7a18972f19b024bd67fea673200a281e82f50015f43a53bc2de644630f9590d2
ISSN 1003-5370
IngestDate Wed Feb 19 01:41:49 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 5
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-p124t-b7a18972f19b024bd67fea673200a281e82f50015f43a53bc2de644630f9590d2
PMID 15957833
ParticipantIDs pubmed_primary_15957833
PublicationCentury 2000
PublicationDate 2005-May
PublicationDateYYYYMMDD 2005-05-01
PublicationDate_xml – month: 05
  year: 2005
  text: 2005-May
PublicationDecade 2000
PublicationPlace China
PublicationPlace_xml – name: China
PublicationTitle Zhongguo Zhong xi yi jie he za zhi
PublicationTitleAlternate Zhongguo Zhong Xi Yi Jie He Za Zhi
PublicationYear 2005
SSID ssib008092609
ssib001103556
ssj0042020
ssib020737681
ssib017477014
ssib009993847
ssib051368380
ssib006576313
ssib007832735
Score 1.769227
Snippet To observe the change of urinary monocyte chemottractant protein-1 (MCP-1) in patients with diabetic nephropathy (DN), and to explore the therapeutic effect...
SourceID pubmed
SourceType Index Database
StartPage 416
SubjectTerms Adult
Aged
Chemokine CCL2 - urine
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - urine
Diterpenes - therapeutic use
Epoxy Compounds
Female
Humans
Immunosuppressive Agents - therapeutic use
Male
Middle Aged
Phenanthrenes - therapeutic use
Phytotherapy
Prospective Studies
Title Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy
URI https://www.ncbi.nlm.nih.gov/pubmed/15957833
Volume 25
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBabFkovpe_0iQ69CRdb8vNYQssSSE8JDb0E2ZZ2VVp7Dw4k--v7yZJtJbSl7cUYiV28M59nvxnNg5B3Uja8TlQVCXjLEf4hVFRLWUS5buOmSOpajQ1MTz7n67P0-Dw7X62Og6yly6F-3-x_WVfyP1rFGvRqq2T_QbPzl2IB99AvrtAwrn-lY9962B7z23e__25aZaP_NoJus-HwIH1zPSgGzUAlg62IgiTZ2JzBdFHCls6qvszNxWJNwzq1sxMUQBBvHPx-3fbdZnPZs_GGXRl2bdg3o8A42V6y_dbMMRuf7LuWJroCCDdzqs-UBWyWtSNfJPLFV6ZNcYhsyfrzptNmuWXCjQGZbKsravYYygJDmboKy0BJux-jlkCvYERcc4w_797qkz1tHZADeAx2BGoQtwHJEWHXoBxulgiIDD7Ii4A4lnEFR28heqDRIjhPhhtXFMH5M4ehhN82W8osEXkprGV0nCDlMXd9MbyMxmlQ7nlv-TMjrzl9SB54h4R-cOh6RFb77WNy78SnXDwhGwcy2mu6gIz2HfUgoxPI6E2Q0Rlk1HR0Ahm1IKMTyGgAsqfk7NPH06N15KdzRDtwwiGqC5mUVcF1UkEAad3mhVYyLwTAIXmZqJLrzFJynQqZibrhrQL5zkWsq6yKW_6M3On6Th0Smir4ATpOVZs3acJzqVNbAg0yH7f4jdkL8tyJ6GLnWrBcTMJ7-dudV-T-gtLX5K7GO6_egEAO9dsRGz8BiuxoqA
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+triptolide+on+urinary+monocyte+chemottractant+protein-1+in+patients+with+diabetic+nephropathy&rft.jtitle=Zhongguo+Zhong+xi+yi+jie+he+za+zhi&rft.au=Song%2C+Hai-xiang&rft.au=Gong%2C+Jing&rft.au=Chen%2C+Wen&rft.date=2005-05-01&rft.issn=1003-5370&rft.volume=25&rft.issue=5&rft.spage=416&rft_id=info%3Apmid%2F15957833&rft_id=info%3Apmid%2F15957833&rft.externalDocID=15957833
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1003-5370&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1003-5370&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1003-5370&client=summon