Analysis of p16INK4a and integrated HPV genomes as progression markers

• Published in: Methods in molecular medicine Vol. 119; p. 73
• Main Authors: Vinokurova, Svetlana, Wentzensen, Nicolas, von Knebel Doeberitz, Magnus
• Format: Journal Article
• Language: English
• Published: United States 2005
• Subjects: Base Sequence; Biomarkers; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - virology; Cyclin-Dependent Kinase Inhibitor p16 - analysis; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Disease Progression; DNA Primers; DNA, Viral - genetics; DNA, Viral - isolation & purification; Female; Humans; Papillomaviridae - genetics; Papillomavirus Infections - diagnosis; Papillomavirus Infections - pathology; Transcription, Genetic; Virus Integration

Most cervical cancers are preventable when the precursor lesions are detected in time. Human papilloma viruses (HPVs) are the main risk factors for cervical cancer development, but there is a high percentage of healthy women infected with HPV that never develop a lesion. Only a small percentage of l...