Immune and inflammation confusion in severe sepsis and effects of bi-immunomodulation therapy: a prospective, randomized, controlled clinical trial
To investigate the immune and inflammation confusion state in severe sepsis and the effects of two way immunomodulation therapy with continuous blood purification (CBP), thymosin alpha1, and combined therapy of CBP and thymosin alpha(1). 91 Patients with severe sepsis aged > 18, with Marshall sco...
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Published in | Zhong hua yi xue za zhi Vol. 89; no. 15; p. 1028 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
21.04.2009
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Abstract | To investigate the immune and inflammation confusion state in severe sepsis and the effects of two way immunomodulation therapy with continuous blood purification (CBP), thymosin alpha1, and combined therapy of CBP and thymosin alpha(1).
91 Patients with severe sepsis aged > 18, with Marshall score>5. were randomly divided into 4 groups: CBP Group (n = 22) undergoing continuous renal replacement therapy (CRRT) or molecular adsorbents recirculating system (MARS) therapy once a day for 3 days in addition to classical Surviving Sepsis Campaign (SSC) therapy, Thymosin alpha(1) Group (n = 23) undergoing subcutaneous injection of thymosin alpha(1) 1.6 mg once a day for 7 days in addition to SSC therapy, Combined Therapy Group (n = 22) undergoing CBP combined with thymosin alpha(1) treatment in addition to SSC therapy, and SSC Group (treatment control group, n = 24) undergoing SSC therapy only. Peripheral blood samples were collected before treatment, and 3 and 7 days after the beginning of treatment (days 4 and 8) |
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AbstractList | To investigate the immune and inflammation confusion state in severe sepsis and the effects of two way immunomodulation therapy with continuous blood purification (CBP), thymosin alpha1, and combined therapy of CBP and thymosin alpha(1).
91 Patients with severe sepsis aged > 18, with Marshall score>5. were randomly divided into 4 groups: CBP Group (n = 22) undergoing continuous renal replacement therapy (CRRT) or molecular adsorbents recirculating system (MARS) therapy once a day for 3 days in addition to classical Surviving Sepsis Campaign (SSC) therapy, Thymosin alpha(1) Group (n = 23) undergoing subcutaneous injection of thymosin alpha(1) 1.6 mg once a day for 7 days in addition to SSC therapy, Combined Therapy Group (n = 22) undergoing CBP combined with thymosin alpha(1) treatment in addition to SSC therapy, and SSC Group (treatment control group, n = 24) undergoing SSC therapy only. Peripheral blood samples were collected before treatment, and 3 and 7 days after the beginning of treatment (days 4 and 8) |
Author | Zhou, Li-Xin Ma, Ming-Yuan Luo, Hong-Tao Yu, Tie-Ou Tan, Jia-Ju Shao, Yong-Hong Qiang, Xin-Hua Li, Yi-Nan Fang, Bin Mao, Ke-Jiang |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19595251$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adjuvants, Immunologic Adult Aged Aged, 80 and over Female Hemofiltration Humans Immunity, Cellular Inflammation Male Middle Aged Prognosis Prospective Studies Sepsis - immunology Sepsis - therapy Thymosin - analogs & derivatives Thymosin - therapeutic use |
Title | Immune and inflammation confusion in severe sepsis and effects of bi-immunomodulation therapy: a prospective, randomized, controlled clinical trial |
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