Fluoroquinolones: antimicrobial activity and chemotherapeutic efficacy with respect to various pathogens in highly dangerous diseases

Comparative in vitro and in vivo efficacy of new fluoroquinolones with respect to pathogens of tularemia, glanders, melioidosis and anthrax was estimated. It was shown that the strains of the tularemia, glanders, melioidosis and anthrax pathogens were in vitro highly susceptible to the new agents. T...

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Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 52; no. 11-12; p. 21
Main Authors Bondareva, T A, Kalininskiĭ, V B, Borisevich, I V, Bondarev, V P, Kozhukhov, V V, Amosov, M Iu, Baramzina, G V, Fomenkov, O O, Krinitsyn, F V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2007
Subjects
Animals
Anthrax - drug therapy
Anthrax - microbiology
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacillus anthracis - drug effects
Burkholderia pseudomallei - drug effects
Cricetinae
Fluoroquinolones - pharmacology
Fluoroquinolones - therapeutic use
Francisella tularensis - drug effects
Glanders - drug therapy
Glanders - microbiology
Guinea Pigs
Melioidosis - drug therapy
Melioidosis - microbiology
Mesocricetus
Tularemia - drug therapy
Tularemia - microbiology
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Summary:Comparative in vitro and in vivo efficacy of new fluoroquinolones with respect to pathogens of tularemia, glanders, melioidosis and anthrax was estimated. It was shown that the strains of the tularemia, glanders, melioidosis and anthrax pathogens were in vitro highly susceptible to the new agents. The experiments on laboratory animals demonstrated that pefloxacin and sparfloxacin had extremely broad spectra and were of special value in emergency prophylaxis of tularemia, glanders, melioidosis and anthrax.
ISSN:0235-2990