Case of methotrexate encephalopathy: findings on diffusion tensor image and correlation with clinical outcome

• Published in: Rinshō shinkeigaku Vol. 47; no. 2-3; p. 79
• Main Authors: Terasawa, Yuka, Nakane, Shunya, Ohnishi, Toshihiro, Harada, Masafumi, Furutani, Kaori, Izumi, Yuishin, Kaji, Ryuji
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.2007
• Subjects: Adult; Antimetabolites, Antineoplastic - adverse effects; Brain - pathology; Diffusion Magnetic Resonance Imaging; Early Diagnosis; Folic Acid Antagonists - adverse effects; Humans; Male; Methotrexate - adverse effects; Neurotoxicity Syndromes - diagnosis; Neurotoxicity Syndromes - pathology

Methotrexate (MTX) is a major cause of treatment-related acute neurotoxicity. We report on clinical and imaging findings of reversibly restricted diffusion in a patient with transient encephalopathy after high dose MTX therapy for osteosarcoma. During the chemotherapy, a 19-year-old man was introduc...