Evaluation of the influence of the bacterial vaccines Pneumo-23 and Act-HIB on the course of the chronic inflammatory process of the respiratory organs in children

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 3; p. 84
• Main Authors: Ryzhov, A A, Katosova, L K, Kostinov, M P, Volkov, I K, Magarshak, O O
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.05.2005
• Subjects: Adolescent; Bacterial Capsules; Child; Child, Preschool; Chronic Disease; Haemophilus Infections - microbiology; Haemophilus Infections - prevention & control; Haemophilus influenzae - isolation & purification; Haemophilus Vaccines - administration & dosage; Humans; Pneumococcal Infections - microbiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Pneumonia, Bacterial - microbiology; Pneumonia, Bacterial - prevention & control; Polysaccharides, Bacterial - administration & dosage; Respiratory Tract Infections - microbiology; Respiratory Tract Infections - prevention & control; Streptococcus pneumoniae - isolation & purification; Vaccines, Acellular - administration & dosage; Vaccines, Conjugate - administration & dosage
• ISSN: 0372-9311; 2686-7613

The effectiveness and safety of vaccination of children having chronic inflammatory lung diseses with Pneumo-23 and Act-HIB were evaluated. The group under study included 38 children having chronic pneumonia, congenital defects of lung development, Kartagener's syndrome, mucoviscidosis; of these children, 25 were vaccinated with Pneumo-23 and 13--with Act-HIB. For comparison a group of 40 children with the same pathology, but not vaccinated, was used. A favorable course of the postvaccinal period was noted. Prior to vaccination Streptococcus pneumoniae in association with Haemophilus influenzae were isolated from all patients; in a year after vaccination with Pneumo-23 these microorganisms were isolated only in monoculture: S. pneumoniae in 3 out of 25 cases (88% elimination) and H. influenzae in 10 out of 25 cases (60% elimination).