Induced pluripotent stem cells

Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost full...

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Bibliographic Details
Published inGenetika Vol. 45; no. 2; p. 160
Main Authors Shevchenko, A I, Medvedev, S P, Mazurok, N A, Zakiian, S M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.2009
Subjects
Animals
Cell Dedifferentiation
Genetic Vectors
Humans
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Transduction, Genetic
Viruses
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Summary:Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC). To date, iPS have been obtained from various differentiated cells of mice and humans. Along with ESC, iPS are highly promising for research and medicine.
ISSN:0016-6758