Cytokine profiling by multiplex immunoassay as an effective approach to assess immunomodulatory activity of bacterial product CANTASTIM
The bacterial product CANTASTIM (CS) is a purified extract of Pseudomonas aeruginosa that induces non-specific protection against bacterial infection, enhances macrophage effector functions and modulates production of cytokines. Most likely, it interacts with components of the innate immune response...
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Published in | Romanian archives of microbiology and immunology Vol. 65; no. 1-2; pp. 53 - 58 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Romania
01.01.2006
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Subjects | |
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Abstract | The bacterial product CANTASTIM (CS) is a purified extract of Pseudomonas aeruginosa that induces non-specific protection against bacterial infection, enhances macrophage effector functions and modulates production of cytokines. Most likely, it interacts with components of the innate immune response. Cytokine production can be used to assess the bioactivity of this product but these biomolecules operate in vivo in a complex regulatory network with reciprocal influences so there is a need for profiling an array of cytokines rather than an individual analysis. Current technology development of multiplex immunoassay for simultaneous measurement of multiple analytes in a single assay has greatly improved the throughput and cost effectiveness of cytokine profiling and proved to be an effective approach to evaluate the immunomodulatory activity of the bacterial product CS. |
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AbstractList | The bacterial product CANTASTIM (CS) is a purified extract of Pseudomonas aeruginosa that induces non-specific protection against bacterial infection, enhances macrophage effector functions and modulates production of cytokines. Most likely, it interacts with components of the innate immune response. Cytokine production can be used to assess the bioactivity of this product but these biomolecules operate in vivo in a complex regulatory network with reciprocal influences so there is a need for profiling an array of cytokines rather than an individual analysis. Current technology development of multiplex immunoassay for simultaneous measurement of multiple analytes in a single assay has greatly improved the throughput and cost effectiveness of cytokine profiling and proved to be an effective approach to evaluate the immunomodulatory activity of the bacterial product CS. |
Author | Lerescu, L Caraş, Iuliana Sălăgeanu, Aurora Tucureanu, C |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17877111$$D View this record in MEDLINE/PubMed |
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Snippet | The bacterial product CANTASTIM (CS) is a purified extract of Pseudomonas aeruginosa that induces non-specific protection against bacterial infection, enhances... |
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SubjectTerms | Cells, Cultured Cytokines - immunology Cytokines - isolation & purification Cytokines - metabolism Humans Immunoassay Immunologic Factors Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Phospholipids - immunology Pseudomonas aeruginosa - immunology Pseudomonas aeruginosa - metabolism |
Title | Cytokine profiling by multiplex immunoassay as an effective approach to assess immunomodulatory activity of bacterial product CANTASTIM |
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