Study on the relationship between the resistance to MTX and the transport protein superfamily of ATP-binding cassette that induces multiple drug resistance

• Published in: Yíchuán Vol. 28; no. 10; p. 1201
• Main Authors: Zhang, Chun-Yu, Feng, Yuan-Xi, Li, Pu, Fu, Song-Bin
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2006
• Subjects: 3T3 Cells; Animals; Antineoplastic Agents - pharmacology; ATP-Binding Cassette Transporters - genetics; Drug Resistance, Multiple - genetics; Drug Resistance, Neoplasm - genetics; Gene Expression Regulation; Methotrexate - pharmacology; Mice; Multidrug Resistance-Associated Proteins - genetics; Oligonucleotide Array Sequence Analysis

A major problem, especially the multidrug resistance, in chemotherapy was the resistance to the chemotherapeutic agents. ATP-binding cassette transporter superfamily that mediated the efflux of drugs was involved in multidrug resistance. In order to understand the relationship between the resistance...